Kill one or kill the many: interplay between mitophagy and apoptosis

DNA vaccines and apoptosis: to kill or not to kill?

The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 1 RNase. Proc. Natl. Acad. Sci. U. S. A. 100:4102-4107. 14. Shinkura, R., et al. 2003. The influence of transcriptional orientation on endogenous switch region function. Nat. Immunol. 4:435–441. 15. Yu, K., Chedin, F., Hsieh, C.L., Wilson, T.E., and Lieber, M.R. 2003. R-loops at immunoglobulin class switch regions in the ch...

Apoptosis: Does stress kill?

A wide variety of cellular stresses can initiate apoptosis, or programmed cell death. Recent work shows that the mechanism involves stress-activated protein kinase pathways, although the targets of these pathways are unknown at present.

Do genes allow inflammation to kill or not to kill?

Acetylate to kill or save

Text by Nicole LeBrasseur [email protected] Acetylate to kill or save M ammalian p53 can kill, or it can save. The end result, according to Knights et al. (page 533), depends on opposing acetylation events that send p53 down disparate paths. The stabilization of p53 following cellular damage can trigger either apoptosis or a reversible cell cycle checkpoint that probably gives cells time ...

To kill or not to kill, that is the question: cytocidal antimalarial drug resistance.

Elucidating mechanisms of antimalarial drug resistance accelerates development of improved diagnostics and the design of new, effective malaria therapy. Recently, several studies have emphasized that chloroquine (CQ) resistance (CQR) can be quantified in two very distinct ways, depending on whether sensitivity to the growth inhibitory effects or parasite-kill effects of the drug are being measu...